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HSE 033
Version 8.0
The Johns Hopkins University and The Johns Hopkins Hospital
Health, Safety and Environment Manual
Safety Policies:
Policy Number
Subject
Page
Last Review Date
HSE033
09/16/2016
1 of 2
Vaccinia Virus and Other Poxviruses
Keywords: Attenuated Virus, Biosafety Level, Biosafety Level 2, BSL, BSL-2, Cowpox, gown, Hazard Sign, Human Tissue,
Monkeypox, Orthopoxvirus, Pathogen Registration, Recombinant DNA, Recombinant Virus, vaccination, Vaccinia, Variola, virus
Table of Contents
I.
II.
III.
IV.
POLICY
REFERENCES
RESPONSIBILITIES
REVIEW CYCLE
Page Number
1
1
1
2
I. POLICY
It is the policy of Johns Hopkins to recommend that all faculty, staff, postdoctoral fellows and students who directly work
with nonhighly attenuated vaccinia viruses, recombinant vaccinia viruses derived from nonhighly attenuated vaccinia strains,
or other nonhighly attenuated Orthopoxviruses that infect humans, (e.g., monkeypox, cowpox, vaccinia and variola) receive
vaccinia vaccination, unless medically contraindicated. Vaccinia vaccination may also be indicated for individuals who enter
rooms or laboratories where these agents are utilized in research, or who enter areas housing animals infected with these agents
or individuals who handle cages, bedding or waste materials from animals infected with these agents prior to decontamination.
For all individuals who qualify, the vaccination is recommended prior to working with these agents and every ten years,
thereafter if use of these agents continues. Vaccination and proof thereof is obtained and verified by the Johns Hopkins
Occupational Health Services, Church Professional Center, 98 N. Broadway, Room 412.
All research utilizing attenuated and non-attenuated vaccinia viruses, recombinant vaccinia viruses and other Orthopoxviruses
that infect humans, must be registered with the Department of Health, Safety and Environment.
All areas utilizing poxvirus shall be posted with yellow colored hazard warning signage at every entry. The signage shall
indicate the Biosafety Level and the specific agent utilized. Visitors, maintenance and other service staff are prohibited from
entry during viral manipulation.
II. REFERENCES
•
•
•
•
Recommendations of the Immunization Practices Advisory Committee on Vaccinia (Smallpox) Vaccine, CDC; MMWR
40, RR-14, 11/14/91
Update on Adult Immunization Recommendations of the Immunization Practices Advisory Committee; MMWR 40,
RRF-123, pp. 7 & 26, 11/15/91
Biosafety in Microbiological and Biomedical Laboratories, U.S. Department of Health and Human Services, Public
Health Service, Centers for Disease Control and National Institutes of Health, HHS Publication No. 21-1112, Fifth
edition, Revised December 2009.
Vaccinia (Smallpox) Vaccine, Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2001,
MMWR 50, RR-10, 6/22/01
III. RESPONSIBILITIES
A.
B.
©
Occupational Health Services (OHS)
1. Provide pre-employment medical screening, periodic medical assessments and employee health evaluations as
indicated.
2. Provide or verify vaccinia virus vaccination to those individuals as indicated. Determine if vaccinia virus
vaccination is medically contraindicated based on established criteria.
Health, Safety and Environment (HSE)
Copyright 2016 by The Johns Hopkins Health System Corporation and/or The Johns Hopkins University
Version 8.0
The Johns Hopkins University and The Johns Hopkins Hospital
Health, Safety and Environment Manual
Safety Policies:
Policy Number
Subject
Page
Last Review Date
HSE033
09/16/2016
2 of 2
Vaccinia Virus and Other Poxviruses
C.
D.
1. Register research involving recombinant DNA, pathogens, oncogens, toxins and human tissue at Johns Hopkins.
2. Annually review research registrations and perform safety surveys of laboratory areas.
3. Provide advice on containment and safe work practices.
Principle Investigators (PI) and Department Management (DM)
1. Register and update annually all protocols involving vaccinia virus with the Department of Health, Safety and
Environment.
2. Inform all faculty, staff, students and postdoctoral fellows directly involved with smallpox or human orthopox virus
research to contact Occupational Health Services.
All faculty, staff, fellows and students
1. Follow established BSL-2 practices, use of appropriate personal protective equipment and properly maintain
laboratory equipment.
IV. REVIEW CYCLE
Annual
©
Copyright 2016 by The Johns Hopkins Health System Corporation and/or The Johns Hopkins University
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