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Common Vesicants - Adult Patients - IV Intermittent Infusion

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Common Vesicants - Adult Patients - IV Intermittent Infusion
Common Vesicants - Adult Patients
Medication
Infiltrate treatment
IV Intermittent Infusion
Peripheral
Central
Max Rate
Miscellaneous
Fosphenytoin
25 mg PE/mL NS or D5
same
150 mg PE/min
Irritant, no treatment necessary.
Phenytoin
Less than 6.7 mg/mL, in NS
only with in-line filter to
decrease precipitation
same
50 mg/min
(20 mg/min is preferred)
No treatment necessary
Vancomycin
≤ 5 mg/mL
(≤ 1.25 gm in 250 mL, ≥ 1.5
gm in 500 mL NS or D5)
Up to 25 mg/mL
(1 gm – 2.5 gm in 100 mL
NS or D5)
PL – ≤ 1.25 gm over 1.25 hrs,
≥ 1.5 gm over 2.5 hrs
(~210 mL/hr)
Irritant, no treatment necessary.
CL – ≥ 1 hr for every 1 gm
(e.g., 1.5 gm over 1.5 hrs)
Cardiovascular Agents
Calcium chloride
(emergency use)
10 mg/mL
(1000 mg in 100 mL NS or
D5)
50 mg/mL
( 5000 mg in 50 mL NS or
D5)
Over 30 – 60 minutes
Hyaluronidase, Warm Applic.
Proc.
Calcium gluconate
(preferred)
0.1 g/mL
(25 gm in 250 mL NS or D5)
same
Over 15 – 30 minutes
Hyaluronidase, Warm Applic.
Proc.
Potassium chloride
0.2 mEq/mL
(10 mEq in 50 mL NS or D5)
0.4 mEq/mL
(20 mEq/50 mL NS or D5)
PL – 20 mEq/hr
Hyaluronidase, Warm Applic.
Proc.
CL – 40 mEq/hr (80 mEq/hr
life threatening and on
monitor)
Last updated 4-3-2011.
Abbreviations: PL: Peripheral Line; CL: Central Line; PE – Phenytoin Equivalents
References: AHFS Drug Information, Lexi-Comp Online, Micromedex; Intravenous Push (IV PUSH) Medications, Adult (PAT030). Version 4.0;
Standard Concentrations for Intravenous (IV) Infusions, Adult (PAT031). Version 4.0; Vesicant Administration: Monitoring and Management of
Infiltration and Extravasation (MDU003). Version 1.3.
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